Transfusion-Related Renal Dysfunction After Cardiac Surgery

Mickael Vourc’h (1, 2) , Antoine Roquilly (1, 2) , Adrien Foucher (2) , Christelle Retière (3, 4) , Fanny Feuillet (1) , Sapna Devi (5) , Hamish E G Mcwilliam (5) , Cecile Braudeau (6, 7, 2) , Geraldine Bourreille (4) , Abderrahman Hachani (8) , Dermot O’kane (5) , Scott N Mueller (5) , Joseph Ischia (5) , Jean-Christian Roussel , Jean-Christophe Rigal (9) , Regis Josien (1, 2) , Bertrand Rozec (1) , Jose A Villadangos (5) , Karim Asehnoune (1, 10)

1 CHU Nantes - Centre Hospitalier Universitaire de Nantes
2 U1064 Inserm - CR2TI - Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology
3 CRCI2NA / Eq 1 - Immunomodulation of the Tumor Microenvironment and Immunotherapy of Thoracic Cancers
4 EFS
5 University of Melbourne
6 ITUN - Institut de transplantation urologie-néphrologie
7 Centre d’Immunomonitorage Nantes Atlantique - CIMNA - Laboratoire d’Immunologie [CHU Nantes]
8 Department of Life Sciences
9 Anesthésiologie et Réanimation [CHU Nantes]
10 Nantes Univ - Nantes Université

Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the composition of blood products and the onset of AKI is unknown. The present study suggests that the transfusion of packed red blood cells containing a high amount of myeloid-related protein 14 (MRP_14) could increase the incidence of AKI after cardiac surgery. In a mouse model, MRP_14 increased the influx of neutrophils in the kidney after ischemia-reperfusion and their ability to damage tubular cells. Higher concentrations of MRP_14 were found in packed red blood cells from female donors or prepared by whole blood filtration

Domaines: Cardiologie et système cardiovasculaire; Chirurgie; Urologie et Néphrologie

Mickael Vourc’h, Antoine Roquilly, Adrien Foucher, Christelle Retière, Fanny Feuillet, et al.. Transfusion-Related Renal Dysfunction After Cardiac Surgery. JACC : Basic to Translational Science, 2022, 7 (7), pp.627 - 638. ⟨10.1016/j.jacbts.2022.02.019⟩. ⟨hal-03832228⟩