Novel cell- and stage-specific transcriptional signatures defining Drosophila neurons, glia and hemocytes

Rosy Sakr (1) , Pierre B Cattenoz (1) , Alexia Pavlidaki (1) , Laura Ciapponi (2) , Marta Marzullo (2) , Hariharan Nivedita (3) , Tina Mukherjee , Angela Giangrande (1)

1 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
2 CNR | IBPM - CNR Istituto di Biologia e Patologia Molecolari [Roma]
3 INSTEM

specific NimA receptor, in agreement with the different environment faced by each cell types. Surprisingly, time represents a key identity parameter, as neurons, hemocytes and glia group more significantly by the stage than by the cell type and larval cells show upregulation of genes involved in chromatin organization and in DNA repair. This latter group of genes is linked to changes in gene expression levels and chromatin organization, revealing a function of these genes beyond DNA repair. Finally, the metabolic profiles reveal cell type-specific signatures and an overall shift from an embryonic, anabolic state to a larval, catabolic state.

Domaines: Sciences du Vivant [q-bio]

Rosy Sakr, Pierre B Cattenoz, Alexia Pavlidaki, Laura Ciapponi, Marta Marzullo, et al.. Novel cell- and stage-specific transcriptional signatures defining Drosophila neurons, glia and hemocytes. 2023. ⟨hal-04296340⟩