APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation

Laurie Arnaud (1) , Philippe Benech (1) , Louise Greetham (1) , Delphine Stephan (1) , Angélique Jimenez (1) , Nicolas Jullien (1) , Laura García-González (1) , Philipp Tsvetkov (1) , François Devred (1) , Ignacio Sancho-Martinez (2) , Juan Carlos Izpisua Belmonte (3) , Kévin Baranger (1) , Santiago Rivera (4, 5, 1) , Emmanuel Nivet (1, 5)

1 INP - Institut de neurophysiopathologie
2 FAES farma
3 Altos Labs
4 AMU - Aix Marseille Université
5 CNRS - Centre National de la Recherche Scientifique

Domaines: Sciences du Vivant [q-bio]

Laurie Arnaud, Philippe Benech, Louise Greetham, Delphine Stephan, Angélique Jimenez, et al.. APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation. Cell Reports, 2022, 40 (7), pp.111200. ⟨10.1016/j.celrep.2022.111200⟩. ⟨hal-03780184⟩