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Heterogeneity of PD-MCI in candidates to subthalamic deep brain stimulation: associated cortical and subcortical modifications

Quentin Devignes 1, 2 Sami Daoudi 1, 2 Romain Viard 3, 2 Renaud Lopes 2, 3 Nacim Betrouni 1, 2 Gregory Kuchcinski 2, 3 Anne-Sophie Rolland 1, 2 Caroline Moreau 2, 1 Luc Defebvre 1, 2 Eric Bardinet 4, 5 Marie Bonnet 6 Christine Brefel-Courbon 7 Christine Delmaire 8 Fouzia El Mountassir 9, 5 Frédérique Fluchère 10, 11 Anne Fradet 12, 13 Caroline Giordana 14 Elodie Hainque 15, 16, 5 Jean-François Houvenaghel 17 Béchir Jarraya 18, 19 Hélène Klinger 20 David Maltête 21, 22 Ana Marques 23, 24, 25 Mylène Meyer 26 Olivier Rascol 27 Tiphaine Rouaud 28 Melissa Tir 29 Thomas Wirth 30, 31, 32 Jean-Christophe Corvol 5, 15 David Devos 1, 2 Kathy Dujardin 1, 2 
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Abstract : Background: Parkinson’s disease mild cognitive impairment (PD-MCI) is frequent and heterogenous. There is no consensus about its influence on subthalamic deep brain stimulation (STN-DBS) outcomes. Objective: To determine the prevalence of PD-MCI and its subtypes in candidates to STN-DBS. Secondarily, we sought to identify MRI structural markers associated with cognitive impairment in these subgroups. Methods: Baseline data from the French multicentric PREDISTIM cohort were used. Candidates to STN-DBS were classified according to their cognitive performance in normal cognition (PD-NC) or PD-MCI. The latter included frontostriatal (PD-FS) and posterior cortical (PD-PC) subtypes. Between-group comparisons were performed on demographical and clinical variables as well as on T1-weighted MRI sequences at the cortical and subcortical levels. Results: 320 patients were included: 167 (52%) PD-NC and 153 (48%) PD-MCI patients. The latter group included 123 (80%) PD-FS and 30 (20%) PD-PC patients. There was no between-group difference regarding demographic and clinical variables. PD-PC patients had significantly lower global efficiency than PD-FS patients and significantly worse performance on visuospatial functions, episodic memory, and language. Compared to PD-NC, PD-MCI patients had cortical thinning and radiomic-based changes in the left caudate nucleus and hippocampus. There were no significant differences between the PD-MCI subtypes. Conclusion: Among the candidates to STN-DBS, a significant proportion has PD-MCI which is associated with cortical and subcortical alterations. Some PD-MCI patients have posterior cortical deficits, a subtype known to be at higher risk of dementia.
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https://hal.archives-ouvertes.fr/hal-03720928
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Submitted on : Tuesday, July 12, 2022 - 11:56:41 AM
Last modification on : Thursday, August 4, 2022 - 5:22:27 PM

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Quentin Devignes, Sami Daoudi, Romain Viard, Renaud Lopes, Nacim Betrouni, et al.. Heterogeneity of PD-MCI in candidates to subthalamic deep brain stimulation: associated cortical and subcortical modifications. Journal of Parkinson's disease, Amsterdam : b : IOS Press, 2022, 12 (5), pp.1507-1526. ⟨10.3233/JPD-223232⟩. ⟨hal-03720928⟩

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