Endothelial cells give a boost to senescence surveillance

Daniel Sampaio Gonçalves (1) , William M Keyes (1)

1 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire

Senescence is a specialized form of cell cycle arrest induced in response to damage and stress. In certain settings, senescent cells can promote their own removal by recruitment of the immune system, a process that is thought to decline in efficiency with age. In this issue of Genes & Development , Yin et al. (pp. 533–549) discover a surprising cross-talk where senescent cells instruct endothelial cells to help organize the clearance of the senescent population. This uncovers yet another layer of complexity in senescent cell biology, with implications for cancer treatment and aging.

Domaines: Sciences du Vivant [q-bio]

Daniel Sampaio Gonçalves, William M Keyes. Endothelial cells give a boost to senescence surveillance. Genes and Development, 2022, 36 (9-10), pp.511-513. ⟨10.1101/gad.349767.122⟩. ⟨hal-03715500⟩