The quantum dot vs. organic dye conundrum for ratiometric FRET-based biosensors: which one would you chose?

Chloé Grazon (1, 2, 3) , Margaret Chern (2) , Patrick Lally (2) , R. Baer (2) , Andy Fan (2) , Sébastien Lecommandoux (3) , Catherine Klapperich (2) , Allison Dennis (2) , James Galagan (2) , Mark Grinstaff (2)

1 ISM - Institut des Sciences Moléculaires
2 BU - Boston University [Boston]
3 Team 3 LCPO : Polymer Self-Assembly & Life Sciences

We report a combined experimental and computational study to systematically compare the nature of the dye, i.e. , organic fluorophore vs. inorganic nanoparticle, and the position of the FRET donor or acceptor on the biosensor performances.

Domaines: Chimie théorique et/ou physique; Chimie analytique

Chloé Grazon, Margaret Chern, Patrick Lally, R. Baer, Andy Fan, et al.. The quantum dot vs. organic dye conundrum for ratiometric FRET-based biosensors: which one would you chose?. Chemical Science, 2022, 13 (22), pp.6715-6731. ⟨10.1039/D1SC06921G⟩. ⟨hal-03690040⟩