9-Cis-13,14-dihydroretinoic acid, a new endogenous mammalian ligand of retinoid X receptor and the active ligand of a potential new vitamin A category: vitamin A5

Ralph Rühl (1) , Wojciech Krężel (2, 3) , Angel de Lera (4)

1 Paprika Bioanalytics BT [Debrecen, Hungary]
2 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
3 FMTS - Fédération de Médecine Translationnelle de Strasbourg
4 Universidade de Vigo

The identity of the endogenous RXR ligand has not been conclusively determined, even though several compounds of natural origin, including retinoids and fatty acids, have been postulated to fulfill this role. Filling this gap, 9-cis-13,14-dihydroretinoic acid (9CDHRA) was identified as an endogenous RXR ligand in mice. This review examines the physiological relevance of various potential endogenous RXR ligands, especially 9CDHRA. The elusive steps in the metabolic synthesis of 9CDHRA, as well as the nutritional/nutrimetabolic origin of 9CDHRA, are also explored, along with the suitability of the ligand to be the representative member of a novel vitamin A class (vitamin A5).

Domaines: Biochimie, Biologie Moléculaire

Ralph Rühl, Wojciech Krężel, Angel de Lera. 9-Cis-13,14-dihydroretinoic acid, a new endogenous mammalian ligand of retinoid X receptor and the active ligand of a potential new vitamin A category: vitamin A5. Nutrition reviews, 2018, 76 (12), pp.929-941. ⟨10.1093/nutrit/nuy057⟩. ⟨hal-03670944⟩