Cycloruthenated compounds as efficient catalyst for asymmetric hydride transfer reaction

Jean-Baptiste Sortais (1) , Laurent Barloy (1) , Claude Sirlin (1) , André de Vries (2) , Johannes de Vries (2) , Michel Pfeffer (1)

1 Institut de Chimie de Strasbourg
2 DSM - DSM Pharmaceutical Chemicals, Advanced Synthesis, Catalysis, and Development

Cycloruthenated complexes obtained by direct C-H activation of enantiopure aromatic primary and secondary amines are efficient catalysts in asymmetric hydride transfer reaction. Reduction of acetophenone has been achieved rapidly with enantiomeric excesses (ee's) ranging from 38 to 89 %. The importance of Ru-C bond in the catalytic efficiency is highlighted.

Mots clés: Cyclometallation; Chirality; Enantioselectivity; Ketones; High-throughput experiments; Reduction; Catalysis; Amines; Ruthenium

Domaines: Chimie de coordination

Jean-Baptiste Sortais, Laurent Barloy, Claude Sirlin, André de Vries, Johannes de Vries, et al.. Cycloruthenated compounds as efficient catalyst for asymmetric hydride transfer reaction. Pure and Applied Chemistry, 2006, 78 (2), pp.457-462. ⟨10.1351/pac200678020457⟩. ⟨hal-03639847⟩