FRET: a tool to study the interaction between apatite and collagen ?

Isabelle dos Santos (1) , Serge Mazères (2) , Michèle Freche (1) , Jean-Louis Lacout (1) , Anne-Marie Sautereau (1)

1 CIRIMAT - Centre interuniversitaire de recherche et d'ingenierie des matériaux
2 IPBS - Institut de pharmacologie et de biologie structurale

Fluorescence Resonance Energy Transfer, FRET, is largely used in biology to demonstrate the occurrence of molecular interactions. In order to investigate the vicinity between collagen and calcium phosphate in bone substitute biomaterial, composites constituted of autofluorescent collagen and apatite doped by europium were synthesized by a precipitation method. The first results show a fluorescence energy transfer between the two fluorescent components and are very promising.

Mots clés: FRET; Luminescence; Composite materials; Apatite; Collagen; Molecular interaction

Domaines: Matériaux

Isabelle dos Santos, Serge Mazères, Michèle Freche, Jean-Louis Lacout, Anne-Marie Sautereau. FRET: a tool to study the interaction between apatite and collagen ?. Materials Letters, 2008, 62 (28), pp.4377-4379. ⟨10.1016/j.matlet.2008.07.035⟩. ⟨hal-03590763⟩