Interesterified palm oil impairs glucose homeostasis and induces deleterious effects in liver of Swiss mice

Josiane Érica Miyamoto , Andressa Reginato , Mariana Portovedo , Raísa Magno dos Santos , Marcella Aparecida Stahl , Hervé Le Stunff (1) , Márcia Queiroz Latorraca , Marise Auxiliadora de Barros Reis , Vanessa Cristina Arantes , Diego Luiz Doneda , Leticia Martins Ignacio-Souza , Adriana Souza Torsoni , Renato Grimaldi , Ana Paula Badan Ribeiro , Marcio Alberto Torsoni , Marciane Milanski

1 NeuroPSI - Institut des Neurosciences Paris-Saclay

Interesterified fats have largely replaced the partially hydrogenated oils which are the main dietary source of trans fat in industrialized food. This process promotes a random rearrangement of the native fatty acids and the results are different triacylglycerol (TAG) molecules without generating trans isomers. The role of interesterified fats in metabolism remains unclear. We evaluated metabolic parameters, glucose homeostasis and inflammatory markers in mice fed with normocaloric and normolipidic diets or hypercaloric and high-fat diet enriched with interesterified palm oil.

Mots clés: Adipose tissue; Fatty acid positional distribuition; Inflammation; Interesterification; Metabolic parameters; Structured lipids; Triacylglycerol structure

Domaines: Neurobiologie; Psychologie et comportements; Sciences cognitives

Josiane Érica Miyamoto, Andressa Reginato, Mariana Portovedo, Raísa Magno dos Santos, Marcella Aparecida Stahl, et al.. Interesterified palm oil impairs glucose homeostasis and induces deleterious effects in liver of Swiss mice. Metabolism, 2020, 112, pp.154350. ⟨10.1016/j.metabol.2020.154350⟩. ⟨hal-03561263⟩