Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe

Marina Boccardi , Andreas Monsch , Clarissa Ferrari , Daniele Altomare , Manfred Berres , Isabelle Bos , Andreas Buchmann , Chiara Cerami , Mira Didic (1) , Cristina Festari , Valentina Nicolosi , Leonardo Sacco , Liesbeth Aerts , Emiliano Albanese , Jean‐marie Annoni , Nicola Ballhausen , Christian Chicherio , Jean‐françois Démonet , Virginie Descloux , Suzie Diener , Daniel Ferreira , Jean Georges , Anton Gietl , Nicola Girtler , Ingo Kilimann , Stefan Klöppel , Nicole Kustyniuk , Patrizia Mecocci , Nathalie Mella , Martina Pigliautile , Katrin Seeher , Steven Shirk , Alessio Toraldo , Andrea Brioschi‐guevara , Kwun Chan , Paul Crane , Alessandra Dodich , Alice Grazia , Nicole Kochan , Fabricio Ferreira Oliveira , Flavio Nobili , Walter Kukull , Oliver Peters , Inez Ramakers , Perminder Sachdev , Stefan Teipel , Pieter Jelle Visser , Michael Wagner , Sandra Weintraub , Eric Westman , Lutz Froelich , Henry Brodaty , Bruno Dubois (2, 3) , Stefano Cappa , David Salmon , Bengt Winblad , Giovanni Frisoni , Matthias Kliegel

1 INS - Institut de Neurosciences des Systèmes
2 ICM - Institut du Cerveau = Paris Brain Institute
3 IM2A - Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre]

Introduction: Harmonized neuropsychological assessment for neurocognitive disorders, an international priority for valid and reliable diagnostic procedures, has been achieved only in specific countries or research contexts. Methods: To harmonize the assessment of mild cognitive impairment in Europe, a workshop (Geneva, May 2018) convened stakeholders, methodologists, academic, and non-academic clinicians and experts from European, US, and Australian harmonization initiatives. Results: With formal presentations and thematic working-groups we defined a standard battery consistent with the U.S. Uniform DataSet, version 3, and homogeneous methodology to obtain consistent normative data across tests and languages. Adaptations consist of including two tests specific to typical Alzheimer's disease and behavioral variant frontotemporal dementia. The methodology for harmonized normative data includes consensus definition of cognitively normal controls, classification of confounding factors (age, sex, and education), and calculation of minimum sample sizes. Discussion: This expert consensus allows harmonizing the diagnosis of neurocognitive disorders across European countries and possibly beyond.

Mots clés: Alzheimer’s disease; cognitive assessment; diagnosis; mild cognitive impairment; mild neurocognitive disorders; standard neuropsychological assessment; Alzheimer’s disease

Domaines: Neurosciences

Marina Boccardi, Andreas Monsch, Clarissa Ferrari, Daniele Altomare, Manfred Berres, et al.. Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2022, 18 (1), pp.29-42. ⟨10.1002/alz.12365⟩. ⟨hal-03553489⟩