[D2 dopaminergic receptor activation enhances the spontaneous release of 3H-GABA in the prefrontal cortex of rats, in vitro. The facilitating role of D1 dopaminergic receptors].

Sylvie Rétaux (1) , Marie-Jo Besson (1) , Jacqueline Penit-Soria (1)

1 Laboratoire de Neurochimie Anatomie

The effects of three D2 dopaminergic agonists on the spontaneous release of 3H-GABA have been studied on rat prefrontal cortical slices. LY171555 (10(-9) M), RU24926 (3 x 10(-8) M) and lisuride (10(-7) M) respectively enhanced the spontaneous release by 25, 20.5 and 23%. These effects were totally reversed by the D2 antagonist sulpiride (10(-5) M). Furthermore, subliminar concentration of RU24926 (10(-9) M) and of the D1 agonist SKF38393 (10(-6) M) induced a clear enhancement of the spontaneous release of 3H-GABA when they were superfused simultaneously. Our results suggest that in the prefrontal cortex, the spontaneous release of 3H-GABA is under an activatory D2 dopaminergic control. The activation of D1 receptors seems to have an enabling effect on this regulation.

Domaines: Neurobiologie; Psychologie et comportements; Sciences cognitives

Sylvie Rétaux, Marie-Jo Besson, Jacqueline Penit-Soria. [D2 dopaminergic receptor activation enhances the spontaneous release of 3H-GABA in the prefrontal cortex of rats, in vitro. The facilitating role of D1 dopaminergic receptors].. Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, 1990, 311 (8), pp.295-300. ⟨hal-03537751⟩