Polymeric self-assemblies for photodynamic therapy: A critical approach

Ugo Till (1, 2) , Laure Gibot (3) , Anne-Françoise Mingotaud (1, 4) , Christophe Mingotaud (1, 4) , Marie-Pierre Rols (3) , Mireille Gaucher (2) , Frédéric Violleau (2, 5) , Patricia Vicendo (1, 4)

1 IMRCP - Interactions moléculaires et réactivité chimique et photochimique
2 INP - PURPAN - Ecole d'Ingénieurs de Purpan
3 IPBS - Institut de pharmacologie et de biologie structurale
4 IMRCP - IDeAS - IMRCP - Interfaces Dynamiques et Assemblages Stimulables
5 CAI - Chimie Agro-Industrielle

The work presented here suggests a new approach in the critical development of polymeric nanovectors for photodynamic therapy (PDT) against cancer. Whereas hundreds of studies quickly jump forward from formation of self-assemblies to biological application without having a thorough examination of the vector solution, we suggest having a parallel assessment of formation/characterization of the nanovectors and biological activity [1]. This is possible by first using a careful physical chemistry characterization of the vectors by both batch techniques (light and neutron scattering, electron microscopy, atomic force microscopy) and Asymmetrical Flow Field-Flow Fractionation (AsFlFFF) coupled to adequate detectors (refractometry, light scattering) [2]. This enables us to fully characterize the vectors regarding purity, size and zeta potential.

Mots clés: Polymeric; Photodynamic

Domaines: Cancer

Ugo Till, Laure Gibot, Anne-Françoise Mingotaud, Christophe Mingotaud, Marie-Pierre Rols, et al.. Polymeric self-assemblies for photodynamic therapy: A critical approach. Photodiagnosis and Photodynamic Therapy, 2017, 17, pp.A23-A24. ⟨10.1016/j.pdpdt.2017.01.053⟩. ⟨hal-03511855⟩