Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial

Subodh Verma , Nitish Dhingra , Javed Butler , Stefan Anker , Joao Pedro Ferreira , Gerasimos Filippatos , James Januzzi , Carolyn Lam , Naveed Sattar , Barbara Peil , Matias Nordaby , Martina Brueckmann , Stuart Pocock , Faiez Zannad , Milton Packer , Jp Ferreira , J George , W Jamal , Fk Welty , M Palmer , T Clayton , Kg Parhofer , Tr Pedersen , B Greenberg , Ma Konstam , Kr Lees , P Carson , W Doehner , A Miller , M Haas , S Pehrson , M Komajda , I Anand , J Teerlink , A Rabinstein , T Steiner , H Kamel , G Tsivgoulis , J Lewis , J Freston , N Kaplowitz , J Mann , J Petrie , S Perrone , S Nicholls , S Janssens , Ea Bocchi , N Giannetti , J Zhang , J Spinar , M-F Seronde , M Boehm , B Merkely , Vk Chopra , M Senni , S Taddi , H Tsutsui , D-J Choi , E Chuquiure , Hpb La Rocca , P Ponikowski , Jrg Juanatey , I Squire , I Pina , R Bernstein , A Cheung , J Green , S Kaul , G Lip , N Marx , P Mccullough , C Mehta , J Rosenstock , B Scirica , S Shah , C Wanner , D Aizenberg , L Cartasegna , F Colombo Berra , H Colombo , M Fernandez Moutin , J Glenny , C Alvarez Lorio , D Anauch , R Campos , A Facta , A Fernandez , R Ahuad Guerrero , L Lobo Márquez , Ra Leon de La Fuente , M Mansilla , M Hominal , E Hasbani , M Najenson , G Moises Azize , H Luquez , L Guzman , H Sessa , M Amuchástegui , O Salomone , E Perna , D Piskorz , M Sicer , D Perez de Arenaza , C Zaidman , S Nani , C Poy , J Resk , R Villarreal , C Majul , T Smith Casabella , S Sassone , A Liberman , G Carnero , A Caccavo , M Berli , N Budassi , J Bono , A Alvarisqueta , J Amerena , K Kostner , A Hamilton , A Begg , J Beltrame , D Colquhoun , G Gordon , A Sverdlov , G Vaddadi , J Wong , J Coller , D Prior , A Friart , A Leone , G Vervoort , P Timmermans , P Troisfontaines , C Franssen , T Sarens , H Vandekerckhove , P van de Borne , F Chenot , J de Sutter , E de Vuyst , P Debonnaire , M Dupont , O Pereira Dutra , Lh Canani , Mdc Vieira Moreira , W de Souza , Lm Backes , L Maia , B de Souza Paolino , Er Manenti , W Saporito , F Villaça Guimarães Filho , T Franco Hirakawa , La Saliba , Fc Neuenschwander , Ca de Freitas Zerbini , G Gonçalves , Y Gonçalves Mello , J Ascenção de Souza , L Beck da Silva Neto , J da Silveira , Jb de Moura Xavier Moraes Junior , Jd de Souza Neto , M Hernandes , Hc Finimundi , Cr Sampaio , E Vasconcellos , Fj Neves Mancuso , Mm Noya Rabelo , M Rodrigues Bacci , F Santos , M Vidotti , Mv Simões , Fl Gomes , C Vieira Nascimento , D Precoma , Fa Helfenstein Fonseca , Ja Ribas Fortes , Pe Leães , D Campos de Albuquerque , Jf Kerr Saraiva , S Rassi , Fa Alves da Costa , G Reis , S Zieroth , D Dion , D Savard , R Bourgeois , C Constance , K Anderson , M-H Leblanc , D Yung , E Swiggum , L Pliamm , Y Pesant , B Tyrrell , T Huynh , J Spiegelman , J-P Lavoie , M Hartleib , R Bhargava , L Straatman , S Virani , A Costa-Vitali , L Hill , M Heffernan , Y Khaykin , J Ricci , M Senaratne , A Zhai , B Lubelsky , M Toma , L Yao , R Mckelvie , L Noronha , M Babapulle , A Pandey , G Curnew , A Lavoie , J Berlingieri , S Kouz , E Lonn , R Chehayeb , Y Zheng , Y Sun , H Cui , Z Fan , X Han , X Jiang , Q Tang , J Zhou , Z Zheng , X Zhang , N Zhang , Y Zhang , A Shen , J Yu , J Ye , Y Yao , J Yan , X Xu , Z Wang , J Ma , Y Li , S Li , S Lu , X Kong , Y Song , G Yang , Z Yao , Y Pan , X Guo , Z Sun , Y Dong , J Zhu , D Peng , Z Yuan , J Lin , Y Yin , O Jerabek , H Burianova , T Fiala , J Hubac , O Ludka , Z Monhart , P Vodnansky , K Zeman , D Foldyna , J Krupicka , I Podpera , L Busak , M Radvan , Z Vomacka , R Prosecky , R Cifkova , V Durdil , J Vesely , J Vaclavik , P Cervinka , A Linhart , T Brabec , R Miklik , H Bourhaial , H-G Olbrich , S Genth-Zotz , E Kemala , B Lemke , M Böhm , S Schellong , W Rieker , T Heitzer , H Ince , M Faghih , A Birkenfeld , A Begemann , A Ghanem , A Ujeyl , S von Haehling , T Dorsel , J Bauersachs , M Prull , F Weidemann , H Darius , G Nickenig , A Wilke , J Sauter , U Rauch-Kroehnert , N Frey , Cp Schulze , W König , L Maier , F Menzel , N Proskynitopoulos , H-H Ebert , H-E Sarnighausen , H-D Düngen , M Licka , C Stellbrink , B Winkelmann , N Menck , Jl López-Sendón , L de La Fuente Galán , Jf Delgado Jiménez , N Manito Lorite , M Pérez de Juan Romero , E Galve Basilio , F Cereto Castro , Jr González Juanatey , Jj Gómez , M Sanmartín Fernández , X Garcia-Moll Marimon , D Pascual Figal , R Bover Freire , E Bonnefoy Cudraz , A Jobbe Duval , D Tomasevic , G Habib , R Isnard , F Picard , P Khanoyan , J-L Dubois-Rande , M Galinier , François Roubille (1, 2) , J Alexandre , D Babuty , N Delarche , J-B Berneau , N Girerd , M Saxena , G Rosano , Z Yousef , C Clifford , C Arden , A Bakhai , C Boos , G Jenkins , C Travill , D Price , L Koenyves , F Lakatos , A Matoltsy , E Noori , Z Zilahi , P Andrassy , S Kancz , G Simon , T Sydo , A Vorobcsuk , Rg Kiss , K Toth , I Szakal , L Nagy , T Barany , A Nagy , E Szolnoki , S Mandal , V Rastogi , B Shah , A Mullasari , J Shankar , V Mehta , A Oomman , U Kaul , S Komarlu , D Kahali , A Bhagwat , V Vijan , Nk Ghaisas , A Mehta , J Kashyap , Y Kothari , S Taddei , M Scherillo , V Zacà , S Genovese , A Salvioni , A Fucili , F Fedele , F Cosmi , M Volpe , C Mazzone , G Esposito , M Doi , H Yamamoto , S Sakagami , S Oishi , Y Yasaka , H Tsuboi , Y Fujino , S Matsuoka , Y Watanabe , T Himi , T Ide , M Ichikawa , Y Kijima , T Koga , S Yuda , K Fukui , T Kubota , M Manita , H Fujinaga , T Matsumura , Y Fukumoto , R Kato , Y Kawai , G Hiasa , Y Kazatani , M Mori , A Ogimoto , M Inoko , M Oguri , M Kinoshita , K Okuhara , N Watanabe , Y Ono , K Otomo , Y Sato , T Matsunaga , A Takaishi , N Miyagi , H Uehara , H Takaishi , H Urata , T Kataoka , H Matsubara , T Matsumoto , T Suzuki , N Takahashi , M Imamaki , T Yoshitama , T Saito , H Sekino , Y Furutani , M Koda , T Shinozaki , K Hirabayashi , R Tsunoda , K Yonezawa , H Hori , M Yagi , M Arikawa , T Hashizume , R Ishiki , T Koizumi , K Nakayama , S Taguchi , M Nanasato , Y Yoshida , S Tsujiyama , T Nakamura , K Oku , M Shimizu , M Suwa , Y Momiyama , H Sugiyama , K Kobayashi , S Inoue , T Kadokami , K Maeno , K Kawamitsu , Y Maruyama , A Nakata , T Shibata , A Wada , H-J Cho , Jo Na , B-S Yoo , J-O Choi , Sk Hong , J-H Shin , M-C Cho , Sh Han , J-O Jeong , J-J Kim , Sm Kang , D-S Kim , Mh Kim , G Llamas Esperon , J Illescas Díaz , P Fajardo Campos , J Almeida Alvarado , A Bazzoni Ruiz , J Echeverri Rico , I Lopez Alcocer , L Valle Molina , C Hernandez Herrera , C Calvo Vargas , Fg Padilla Padilla , I Rodriguez Briones , Ejjr Chuquiure Valenzuela , Me Aguilera Real , J Carrillo Calvillo , M Alpizar Salazar , Jl Cervantes Escárcega , R Velasco Sanchez , N Al - Windy , L van Heerebeek , L Bellersen , H-P Brunner-La Rocca , J Post , Gcm Linssen , M van de Wetering , R Peters , R van Stralen , R Groutars , P Smits , A Yilmaz , Wem Kok , P van Der Meer , P Dijkmans , R Troquay , Ap van Alem , R van de Wal , L Handoko , Icd Westendorp , Pfmm van Bergen , Bjwm Rensing , P Hoogslag , B Kietselaer , Ja Kragten , Fr den Hartog , A Alings , L Danilowicz-Szymanowicz , G Raczak , W Piesiewicz , W Zmuda , W Kus , P Podolec , W Musial , G Drelich , G Kania , P Miekus , S Mazur , A Janik , J Spyra , J Peruga , P Balsam , B Krakowiak , J Szachniewicz , M Ginel , J Grzybowski , W Chrustowski , P Wojewoda , A Kalinka , A Zurakowski , R Koc , M Debinski , W Fil , M Kujawiak , J Forys , M Kasprzak , M Krol , P Michalski , E Mirek-Bryniarska , K Radwan , G Skonieczny , K Stania , G Skoczylas , A Madej , J Jurowiecki , B Firek , B Wozakowska-Kaplon , K Cymerman , J Neutel , K Adams , P Balfour , A Deswal , A Djamson , P Duncan , M Hong , C Murray , D Rinde-Hoffman , S Woodhouse , R Macnevin , B Rama , C Broome-Webster , S Kindsvater , D Abramov , M Barettella , S Pinney , J Herre , A Cohen , K Vora , K Challappa , S West , S Baum , J Cox , S Jani , A Karim , A Akhtar , O Quintana , L Paukman , R Goldberg , Z Bhatti , M Budoff , E Bush , A Potler , R Delgado , B Ellis , J Dy , J Fialkow , R Sangrigoli , K Ferdinand , C East , S Falkowski , S Donahoe , R Ebrahimi , G Kline , B Harris , R Khouzam , N Jaffrani , N Jarmukli , N Kazemi , M Koren , K Friedman , W Herzog , J Silva Enciso , D Cheung , M Grover-Mckay , P Hauptman , D Mikhalkova , V Hegde , J Hodsden , S Khouri , F Mcgrew , R Littlefield , P Bradley , B Mclaurin , S Lupovitch , I Labin , V Rao , M Leithe , M Lesko , N Lewis , D Lombardo , S Mahal , V Malhotra , I Dauber , A Banerjee , J Needell , G Miller , L Paladino , K Munuswamy , M Nanna , E Mcmillan , M Mumma , M Napoli , W Nelson , T O'Brien , A Adlakha , A Onwuanyi , H Serota , J Schmedtje , A Paraschos , R Potu , C Sai-Sudhakar , M Saltzberg , A Sauer , P Shah , H Skopicki , H Bui , K Carr , G Stevens , N Tahirkheli , J Tallaj , K Yousuf , B Trichon , J Welker , P Tolerico , A Vest , R Vivo , X Wang , R Abadier , S Dunlap , N Weintraub , A Malik , P Kotha , V Zaha , G Kim , N Uriel , T Greene , A Salacata , R Arora , R Gazmuri , J Kobayashi , B Iteld , R Vijayakrishnan , R Dab , Z Mirza , V Marques , M Nallasivan , D Bensimhon , B Peart , H Saint-Jacques , K Barringhaus , J Contreras , A Gupta , S Koneru , V Nguyen

1 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
2 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]

Domaines: Sciences du Vivant [q-bio]

Subodh Verma, Nitish Dhingra, Javed Butler, Stefan Anker, Joao Pedro Ferreira, et al.. Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial. The Lancet. Diabetes & Endocrinology , 2021, ⟨10.1016/S2213-8587(21)00292-8⟩. ⟨hal-03470953⟩