DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

Federica Quaglia (1) , Bálint Mészáros (2) , Edoardo Salladini (1) , András Hatos (1) , Rita Pancsa (3) , Lucía B Chemes (4) , Mátyás Pajkos (5) , Tamas Lazar (6) , Samuel Peña-Díaz (7) , Jaime Santos (7) , Veronika Ács (3) , Nazanin Farahi (6) , Erzsébet Fichó (3) , Maria Cristina Aspromonte (1) , Claudio Bassot (8) , Anastasia Chasapi (9) , Norman E Davey (10) , Radoslav Davidović (11) , Laszlo Dobson (3) , Arne Elofsson (8) , Gábor Erdős (5) , Pascale Gaudet (12) , Michelle Giglio (13) , Juliana Glavina (4) , Javier Iserte (14) , Valentín Iglesias (7) , Zsófia Kálmán (15) , Matteo Lambrughi (16) , Emanuela Leonardi (1) , Sonia Longhi (17) , Sandra Macedo-Ribeiro (18) , Emiliano Maiani (16) , Julia Marchetti (19) , Cristina Marino-Buslje (14) , Attila Mészáros (6) , Alexander Miguel Monzon (1) , Giovanni Minervini (1) , Suvarna Nadendla (13) , Juliet F Nilsson (17) , Marian Novotný (20) , Christos A Ouzounis (21) , Nicolás Palopoli (19) , Elena Papaleo (22) , Pedro José Barbosa Pereira (18) , Gabriele Pozzati (8) , Vasilis J Promponas (23) , Jordi Pujols (7) , Alma Carolina Sanchez Rocha (24) , Martin Salas (19) , Luciana Rodriguez Sawicki (19) , Eva Schad (3) , Aditi Shenoy (8) , Tamás Szaniszló (5) , Konstantinos D Tsirigos (25) , Nevena Veljkovic (11) , Gustavo Parisi (19) , Salvador Ventura (7) , Zsuzsanna Dosztányi (5) , Peter Tompa (6) , Silvio C E Tosatto (1) , Damiano Piovesan (1)

1 Unipd - Università degli Studi di Padova = University of Padua
2 EMBL - European Molecular Biology Laboratory [Heidelberg]
3 Research Centre for Natural Sciences
4 UNSAM - Universidad Nacional de San Martin
5 ELTE - Eötvös Loránd University
6 VUB - Vrije Universiteit Brussel
7 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
8 Stockholm University
9 CERTH - Centre for Research and Technology Hellas
10 Chester Beatty Laboratories
11 University of Belgrade [Belgrade]
12 SIB - Swiss Institute of Bioinformatics [Genève]
13 University of Maryland School of Medicine
14 Fundación Instituto Leloir [Buenos Aires]
15 Pázmány Péter Catholic University
16 Danish Cancer Society Research Center
17 AFMB - Architecture et fonction des macromolécules biologiques
18 Universidade do Porto = University of Porto
19 UNQ - Universidad Nacional de Quilmes
20 Faculty of Science
21 Aristotle University of Thessaloniki
22 DTU - Danmarks Tekniske Universitet = Technical University of Denmark
23 UCY - University of Cyprus [Nicosia]
24 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
25 Wellcome Trust Genome Campus

The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

Domaines: Sciences du Vivant [q-bio]

Federica Quaglia, Bálint Mészáros, Edoardo Salladini, András Hatos, Rita Pancsa, et al.. DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation. Nucleic Acids Research, 2022, 50 (D1), pp.D480-D487. ⟨10.1093/nar/gkab1082⟩. ⟨hal-03463975⟩