Clash of the titans: interferons and SARS-CoV-2

Nolwenn Jouvenet (1) , Caroline Goujon (2) , Arinjay Banerjee (3, 4)

1 Signalisation antivirale - Virus sensing and signaling
2 IRIM - Institut de Recherche en Infectiologie de Montpellier
3 U of S - University of Saskatchewan [Saskatoon, Canada]
4 University of Waterloo [Waterloo]

Interferons are our first line of defense against invading viruses. However, viruses encode effector proteins that can modulate human interferon responses. In this forum article, we highlight important discoveries and discuss outstanding questions that will enable us to better understand the nuances of this evolutionary battle between interferons and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Mots clés: SARS-CoV-2; innate immunity; interferon; interferon-stimulated genes; virus–host interaction

Domaines: Maladies infectieuses; Immunité innée; Maladies émergentes; Virologie

Nolwenn Jouvenet, Caroline Goujon, Arinjay Banerjee. Clash of the titans: interferons and SARS-CoV-2. Trends in Immunology, 2021, 42 (12), pp.1069-1072. ⟨10.1016/j.it.2021.10.009⟩. ⟨hal-03447813⟩