One-step, kit-based radiopharmaceuticals for molecular SPECT imaging: a versatile diphosphine chelator for 99m Tc radiolabelling of peptides

Ingebjørg N Hungnes , Fahad Al-Salemee , Peter J Gawne , Thomas R Eykyn , R. Andrew Atkinson (1) , Samantha y A Terry , Fiona Clarke , Philip J Blower , Paul G Pringle , Michelle T Ma

1 IPBS - Institut de pharmacologie et de biologie structurale

We report a versatile diphosphine platform for 99m Tc radiolabelling of peptides. The diphosphine-peptide conjugate can be radiolabelled with 99m Tc in a single step, and the new radiotracer is capable of receptor-targeted imaging of disease in vivo .

Mots clés: technetium-99m; phosphine; RGD; integrin; SPECT imaging

Domaines: Sciences du Vivant [q-bio]

Ingebjørg N Hungnes, Fahad Al-Salemee, Peter J Gawne, Thomas R Eykyn, R. Andrew Atkinson, et al.. One-step, kit-based radiopharmaceuticals for molecular SPECT imaging: a versatile diphosphine chelator for 99m Tc radiolabelling of peptides. Dalton Transactions, 2021, 50 (44), pp.16156-16165. ⟨10.1039/d1dt03177e⟩. ⟨hal-03435251⟩