SCCS Opinion on Kojic Acid - SCCS/1637/21 - Preliminary version

U. Bernauer , L. Bodin (1, 2) , Q. Chaudhry , P.J. Coenraad , M. Dusinska , J. Ezendam , E. Gaffet (3, 2) , C. L. Galli , B. Granum , E. Panteri , V. Rogiers , Ch. Rousselle (4, 2) , M. Stepnik , T. Vanhaecke , S. Wijnhoven , A. Koutsodimou , W. Uter , N. Von Goetz

1 CEA - CEA- Saclay
2 SCCS - Scientific Committee for Consumer Safety (SCCS)
3 IJL - Institut Jean Lamour
4 ANSES - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail

Kojic acid SCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C.L. Galli, B. Granum, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke (Rapporteur), S. Wijnhoven SCCS external experts: A. Koutsodimou, W. Uter, N. von Goetz Contact: [e-mail] On request from: European Commission SCCS Number: SCCS/1637/21 Adopted on: 26-27 October 2021 Conclusion of the opinion: (1) In light of the data provided and taking under consideration the concerns related to potential endocrine disrupting properties of Kojic acid, does the SCCS consider Kojic acid safe when used in cosmetic products up to a maximum concentration of 1 %? On the basis of the safety assessment, and considering the concerns related to potential endocrine disrupting properties of Kojic acid, the SCCS is of the opinion that the concentration of 1% Kojic acid is not safe for the intended use in cosmetic products. (2) Alternatively, what is according to the SCCS the maximum concentration considered safe for use of Kojic acid in cosmetic products? Without specific data on the different cosmetic products containing Kojic acid, the SCCS is unable to advice on the safe concentration of Kojic acid in individual cosmetic products. As an example, for the combined twice a day use of face cream and hand cream, the maximum concentration of Kojic acid should not exceed 0.04%. (3) Does the SCCS have any further scientific concerns with regard to the use of Kojic acid in cosmetic products? As Kojic acid is sometimes added to peeling agents, a weakened skin barrier may be of additional concern because of greater dermal absorption. Only the topical use of Kojic acid in cosmetics has been considered in this Opinion. Other uses (e.g. food) of natural or synthetic sources have not been considered. As far as the derivatives of Kojic acid are concerned, e.g. esters of Kojic acid such as Kojic acid dipalmitate and Kojic acid isopalmitate, and derivatives such as chloro-Kojic acid, these have not been included in this Opinion as no data has been submitted. Keywords: SCCS, revision, scientific opinion, Kojic acid, CAS No 501-30-4, EC No 207-922-4, Regulation 1223/2009 Opinion to be cited as: SCCS (Scientific Committee on Consumer Safety), scientific opinion on Kojic acid, preliminary version of 26-27 October 2021, SCCS/1637/21.

Mots clés: SCCS; revision; scientific opinion; Kojic acid; CAS No 501-30-4; EC No 207-922-4; Regulation 1223/2009

Domaines: Science des matériaux [cond-mat.mtrl-sci]

U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraad, M. Dusinska, et al.. SCCS Opinion on Kojic Acid - SCCS/1637/21 - Preliminary version. Scientific Committee for Consumer Safety (European Commission). 2021. ⟨hal-03418344⟩