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Mg2+ Transporters in Digestive Cancers

Abstract : Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is regulated by Mg2+ transporters including Mitochondrial RNA Splicing Protein 2 (MRS2), Transient Receptor Potential Cation Channel Subfamily M, Member 6/7 (TRPM6/7), Magnesium Transporter 1 (MAGT1), Solute Carrier Family 41 Member 1 (SCL41A1), and Cyclin and CBS Domain Divalent Metal Cation Transport Mediator (CNNM) proteins. Recent data show that Mg2+ transporters may regulate several cancer cell hallmarks. In this review, we describe the expression of Mg2+ transporters in digestive cancers, the most common and deadliest malignancies worldwide. Moreover, Mg2+ transporters’ expression, correlation and impact on patient overall and disease-free survival is analyzed using Genotype Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. Finally, we discuss the role of these Mg2+ transporters in the regulation of cancer cell fates and oncogenic signaling pathways.
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Submitted on : Monday, April 12, 2021 - 4:59:51 PM
Last modification on : Friday, October 8, 2021 - 4:28:17 PM
Long-term archiving on: : Tuesday, July 13, 2021 - 7:09:02 PM


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Julie Auwercx, Pierre Rybarczyk, Philippe Kischel, Isabelle Dhennin-Duthille, Denis Chatelain, et al.. Mg2+ Transporters in Digestive Cancers. Nutrients, MDPI, 2021, 13 (1), pp.210. ⟨10.3390/nu13010210⟩. ⟨hal-03195960⟩



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