COVID-19 and metabolic disease: mechanisms and clinical management

Charlotte Steenblock (1) , Peter Schwarz (1, 2) , Barbara Ludwig (1, 3, 2, 4) , Andreas Linkermann (1) , Paul Zimmet (5) , Konstantin Kulebyakin (6) , Vsevolod Tkachuk (6) , Alexander Markov (7) , Hendrik Lehnert (8) , Martin Hrabě de Angelis (9, 10, 11) , Hannes Rietzsch (1) , Roman Rodionov (1) , Kamlesh Khunti (12) , David Hopkins (13) , Andreas Birkenfeld (1, 2, 13, 14, 15, 10) , Bernhard Boehm (16, 17) , Richard Holt (18) , Jay Skyler (19) , J Hans Devries (20, 21) , Eric Renard (22, 23) , Robert Eckel (24) , K George M M Alberti (25) , Bruno Geloneze (26) , Juliana Chan (27) , Jean Claude Mbanya (28) , Henry Onyegbutulem (29) , Ambady Ramachandran (30) , Abdul Basit (31) , Mohamed Hassanein (32) , Gavin Bewick (13) , Giatgen Spinas (3) , Felix Beuschlein (3) , Rüdiger Landgraf (33) , Francesco Rubino (13, 34) , Geltrude Mingrone (13, 35, 36) , Stefan Bornstein (1, 2, 3, 13)

1 TU Dresden - Technische Universität Dresden = Dresden University of Technology
2 University Hospital Carl Gustav Carus [Dresden, Germany]
3 University hospital of Zurich [Zurich]
4 Paul Langerhans Institute of the Helmholtz Center Munich
5 Monash University [Melbourne]
6 MSU - Lomonosov Moscow State University
7 SPbU - St Petersburg State University
8 University of Salzburg
9 Helmholtz Zentrum München = German Research Center for Environmental Health
10 DZD - German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg]
11 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
12 University of Leicester
13 King‘s College London
14 Universitätsklinikum Tübingen - University Hospital of Tübingen
15 University of Tübingen
16 Tan Tock Seng Hospital
17 Nanyang Technological University [Singapour]
18 University of Southampton
19 UMMSM - University of Miami Leonard M. Miller School of Medicine
20 Amsterdam UMC - Amsterdam University Medical Center
21 Profil Institute for Metabolic Research GmbH
22 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
23 IGF - Institut de Génomique Fonctionnelle
24 University of Colorado Anschutz [Aurora]
25 Imperial College London
26 UNICAMP - Universidade Estadual de Campinas = University of Campinas
27 CUHK - The Chinese University of Hong Kong [Hong Kong]
28 University of Yaoundé [Cameroun]
29 UNN - University of Nigeria
30 Chennai, India
31 University of Karachi
32 Dubai Hospital
33 Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
34 Kings College Hopsital
35 Fondazione Policlinico Universitario Agostino Gemelli IRCCS
36 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]

Up to 50% of the people who have died from COVID-19 had metabolic and vascular disorders. Notably, there are many direct links between COVID-19 and the metabolic and endocrine systems. Thus, not only are patients with metabolic dysfunction (eg, obesity, hypertension, non-alcoholic fatty liver disease, and diabetes) at an increased risk of developing severe COVID-19 but also infection with SARS-CoV-2 might lead to new-onset diabetes or aggravation of pre-existing metabolic disorders. In this Review, we provide an update on the mechanisms of how metabolic and endocrine disorders might predispose patients to develop severe COVID-19. Additionally, we update the practical recommendations and management of patients with COVID-19 and post-pandemic. Furthermore, we summarise new treatment options for patients with both COVID-19 and diabetes, and highlight current challenges in clinical management.

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie

Charlotte Steenblock, Peter Schwarz, Barbara Ludwig, Andreas Linkermann, Paul Zimmet, et al.. COVID-19 and metabolic disease: mechanisms and clinical management. The Lancet. Diabetes & Endocrinology , 2021, 9 (11), pp.786-798. ⟨10.1016/S2213-8587(21)00244-8⟩. ⟨hal-03379012⟩