Assessment of in vitro and in vivo Antimicrobial Activity of an Isonitrosomalononitrile Silver(I) Salt

Jean Michel Brunel (1) , Marie Colmont (2) , Jean Michel Brunel (3)

1 TMCD2 - Transporteurs membranaires, chimioresistance et drug-design
2 UCCS - Unité de Catalyse et Chimie du Solide - UMR 8181
3 CRCM - Centre de Recherche en Cancérologie de Marseille

The design and evaluation of antimicrobial activities of an isonitrosomalononitrile silver(I) salt was reported. This highly stable water-soluble silver salt shows Minimum Inhibitory Concentrations (MIC) values ranging from 0.15 to 5 µg/mL towards both sensitive and resistant Gram-positive and negative bacteria. Furthermore, this silver salt has been investigated for its ability to treat a S. aureus infected Galleria mellonella larvae animal model with promising results. Thus, our results demonstrated that 80% of the treated larvae survived after 24h with respect to 10% of the untreated ones, respectively.

Domaines: Maladies infectieuses; Chimie

Jean Michel Brunel, Marie Colmont, Jean Michel Brunel. Assessment of in vitro and in vivo Antimicrobial Activity of an Isonitrosomalononitrile Silver(I) Salt. Journal of Medicinal Chemistry, 2021, ⟨10.16966/2578-9589.117⟩. ⟨hal-03373137⟩