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Generic Solving of One-compartment Toxicokinetic Models

Abstract : This paper gives the full analytical solution of the generic set of ordinary differential equations that define onecompartment toxicokinetic models. These models describe the uptake and elimination processes that occur within living organisms when exposed to chemical substances. The models solved in this paper consider living organisms as a unique compartment, into which a parent compound enters via several possible exposure routes and from which it is eliminated as well as its potential metabolites. Benefiting from generic solutions of onecompartment toxicokinetic models is particularly useful when fitting them to experimental data, facilitating the writing of the inference algorithms leading to parameter estimates. Additionally, these models are of crucial interest in environmental risk assessment for the calculation of bioaccumulation metrics as required by regulators in support of decision-making when they evaluate dossiers for marketing authorisation of active substances.
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https://hal.archives-ouvertes.fr/hal-03362341
Contributor : Sandrine Charles Connect in order to contact the contributor
Submitted on : Friday, October 1, 2021 - 5:33:34 PM
Last modification on : Wednesday, October 6, 2021 - 3:37:06 AM

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Sandrine Charles, Aude Ratier, Christelle Lopes. Generic Solving of One-compartment Toxicokinetic Models. Journal of Exploratory Research in Pharmacology, Xia & He Publishing, 2021, ⟨10.14218/JERP.2021.00024⟩. ⟨hal-03362341⟩

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