Human Antibody Response to Aedes aegypti Saliva in an Urban Population in Bolivia: A New Biomarker of Exposure to Dengue Vector Bites

Souleymane Doucoure , François Mouchet (1) , Amandine Cournil (2) , Gilbert Le Goff (1) , Sylvie Cornélie (1) , Yelin Roca (3) , Mabel Guerra Giraldez , Barja Simon Zaira (3) , Roxanna Loayza (3) , Dorothée Missé (1) , Vargas Flores Jorge (3) , Annie Walter (1) , Christophe Rogier (4) , Jean-Pierre Herve (1) , Franck Remoue (1)

1 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
2 TransVIHMI - Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes
3 CENETROP - Centro Nacional de Enfermedades Tropicales [Santa Cruz de la Sierra, Bolivia]
4 IMTSSA - Institut de Médecine Tropicale du Service de Santé des Armées

Aedes mosquitoes are important vectors of re-emerging diseases in developing countries, and increasing exposure to Aedes in the developed world is currently a source of concern. Given the limitations of current entomologic methods, there is a need for a new effective way for evaluating Aedes exposure. Our objective was to evaluate specific antibody responses to Aedes aegypti saliva as a biomarker for vector exposure in a dengue-endemic urban area. IgG responses to saliva were strong in young children and steadily waned with age. Specific IgG levels were significantly higher in persons living in sites with higher Ae. aegypti density, as measured by using entomologic parameters. Logistic regression showed a significant correlation between IgG to saliva and exposure level, independently of either age or sex. These results suggest that antibody responses to saliva could be used to monitor human exposure to Aedes bites.

Domaines: Sciences du Vivant [q-bio]

Souleymane Doucoure, François Mouchet, Amandine Cournil, Gilbert Le Goff, Sylvie Cornélie, et al.. Human Antibody Response to Aedes aegypti Saliva in an Urban Population in Bolivia: A New Biomarker of Exposure to Dengue Vector Bites. American Journal of Tropical Medicine and Hygiene, 2012, 87 (3), pp.504-510. ⟨10.4269/ajtmh.2012.11-0477⟩. ⟨hal-03359027⟩