Serotonergic projections from the nodose ganglia to the nucleus tractus solitarius: an immunohistochemical and double labeling study in the rat

Anne Nosjean (1) , Claude Compoint (2) , Catherine Buisseret-Delmas (2) , Hakan S. Orer (2) , Nacera Merahi (2) , Jean-Jacques Puizillout (3) , Raul Laguzzi (1)

1 Neuropsychopharmacologie moléculaire, cellulaire et fonctionnelle
2 Laboratoire de physiologie de la motricité
3 LNB - Laboratoire de Neurobiologie

Possible projections of serotonin (5-HT)-immunoreactive neurons in the nodose ganglia (NG) to the nucleus tractus solitarius (NTS) were investigated in the rat using a double labeling method combining retrograde transport and 5-HT immunohistochemistry. After injection of a complex of colloidal gold-apo-horseradish peroxidase into the medio-caudal and commissural parts of the NTS, most of the 5-HT-immunoreactive neurons were found to be labelled by the gold complex. The present study provides direct evidence for the existence, in the rat, of a serotonergic NG-NTS system. This system may be involved in the regulation of blood pressure and vigilance states.

Domaines: Neurobiologie; Psychologie et comportements; Sciences cognitives

Anne Nosjean, Claude Compoint, Catherine Buisseret-Delmas, Hakan S. Orer, Nacera Merahi, et al.. Serotonergic projections from the nodose ganglia to the nucleus tractus solitarius: an immunohistochemical and double labeling study in the rat. Neuroscience Letters, 1990, 114 (1), pp.22-26. ⟨10.1016/0304-3940(90)90422-6⟩. ⟨hal-03301305⟩