Study of the influence of autoclave sterilization on the properties of citrate functionalized iron oxide nanoparticles

Thomas Girardet (1) , Amel Cherraj (1) , Astrid Pinzano (2) , Christel Henrionnet (2) , Franck Cleymand (1) , Solenne Fleutot (1)

1 IJL - Institut Jean Lamour
2 IMoPA - Ingénierie Moléculaire et Physiopathologie Articulaire

Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are widely used in various areas of the biomedical field: for diagnosis (Magnetic Resonance Imaging), for therapeutic applications (hyperthermia, nanovectorization). These applications require a good stability in water and no aggregation of SPIONs, with well-controlled physicochemical and magnetic properties. In this work, SPIONs functionalized by citrate ligands are synthesized in a one-step process with the aim of producing stable water-dispersible nanoparticles with a well-crystallized spinel structure. Microwave technology is implemented to achieve this objective given the ease, speed and reproducibility of the method. For their future use in biomedical applications, the sterilization of these SPIONs are essential by an autoclave treatment. The influence of this treatment on the physicochemical and magnetic properties of the SPIONs is determined by a systematic characterization before and after sterilization by Transmission Electronic Microscopy, Dynamic Light Scattering, X-ray Diffraction, Fourier Transformed Infra-Red, ThermoGravimetric Analysis and magnetic measurements.

Mots clés: iron oxide nanoparticles; synthesis; functionalization; sterilization; physicochemical properties; magnetic properties

Domaines: Chimie

Thomas Girardet, Amel Cherraj, Astrid Pinzano, Christel Henrionnet, Franck Cleymand, et al.. Study of the influence of autoclave sterilization on the properties of citrate functionalized iron oxide nanoparticles. Pure and Applied Chemistry, 2021, pp.000010151520210303. ⟨10.1515/pac-2021-0303⟩. ⟨hal-03279293⟩