Requirement of MgtC for Brucella suis Intramacrophage Growth: a Potential Mechanism Shared by Salmonella enterica and Mycobacterium tuberculosis for Adaptation to a Low-Mg2+ Environment

Jean-Philippe Lavigne , David O'Callaghan , Anne‐beatrice Blanc‐potard (1)

1 DIMNP - Dynamique des interactions membranaires normales et pathologiques

ABSTRACT A Brucella suis mgtC mutant is defective for growth within macrophages and in low-Mg 2+ medium. These phenotypes are strikingly similar to those observed with mgtC mutants from Salmonella enterica and Mycobacterium tuberculosis , two other pathogens that proliferate within phagosomes. MgtC appears as a remarkable virulence factor that would have been acquired by distantly related intracellular pathogens to contribute to the adaptation to a low-Mg 2+ environment in the phagosome.

Domaines: Sciences du Vivant [q-bio]

Jean-Philippe Lavigne, David O'Callaghan, Anne‐beatrice Blanc‐potard. Requirement of MgtC for Brucella suis Intramacrophage Growth: a Potential Mechanism Shared by Salmonella enterica and Mycobacterium tuberculosis for Adaptation to a Low-Mg2+ Environment. Infection and Immunity, 2005, 73 (5), pp.3160-3163. ⟨10.1128/IAI.73.5.3160-3163.2005⟩. ⟨hal-03247036⟩