Epilepsy and pregnancy: What should the neurologists do?

S. Dupont (1, 2) , L. Vercueil (3)

1 ICM - Institut du Cerveau = Paris Brain Institute
2 CHU Pitié-Salpêtrière [AP-HP]
3 GIN - [GIN] Grenoble Institut des Neurosciences

Epilepsy is one of the most common chronic disorders affecting women of childbearing age. Unfortunately, many women with epilepsy (WWE) still report not receiving key information about pregnancy. They obviously need information about epilepsy and pregnancy prior to conception with a particular emphasis on effective birth control (i.e. contraception), necessity to plan pregnancy, antiepileptic drugs optimization, and folate supplementation. The risks associated with use of antiepileptic drugs during pregnancy have to be balanced against fetal and maternal risks associated with uncontrolled seizures. This report reviews evidence-based counseling and management strategies concerning maternal and fetal risks associated with seizures, teratogenic risks associated with antiepileptic drug exposure with a special emphasis on developmental and behavioural outcomes of children exposed to intra utero antiepileptic drugs.

Mots clés: Counselling; Education; Epilepsy; Pregnancy

Domaines: Sciences du Vivant [q-bio]

S. Dupont, L. Vercueil. Epilepsy and pregnancy: What should the neurologists do?. Revue Neurologique, 2021, 177 (3), pp.168-179. ⟨10.1016/j.neurol.2021.01.003⟩. ⟨hal-03182532⟩