Current Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy

Magdalena Rudzińska (1) , Cenk Daglioglu (2) , Lyudmila Savvateeva (1) , Fatma Necmiye Kaci (3) , Rodolphe Antoine (4) , Andrey Zamyatnin Jr (1, 5)

1 Sechenov First Moscow State Medical University
2 IZTECH - Izmir Institute of Technology
3 ETU - Erzurum Technical University
4 iLM - SPECTROBIO - iLM - Spectrométrie des biomolécules et agrégats
5 Belozersky Institute of Physico-Chemical Biology

In cancer treatments, many natural and synthetic products have been examined; among them, protease inhibitors are promising candidates for anti-cancer agents. Since dysregulated proteolytic activities can contribute to tumor development and metastasis, antagonization of proteases with tailored inhibitors is an encouraging approach. Although adverse effects of early designs of these inhibitors disappeared after the introduction of next-generation agents, most of the proposed inhibitors did not pass the early stages of clinical trials due to their nonspecific toxicity and lack of pharmacological effects. Therefore, new applications that modulate proteases more specifically and serve their programmed way of administration are highly appreciated. In this context, nanosized drug delivery systems have attracted much attention because preliminary studies have demonstrated that the therapeutic capacity of inhibitors has been improved significantly with encapsulated formulation as compared to their free forms. Here, we address this issue and discuss the current application and future clinical prospects of this potential combination towards targeted protease-based cancer therapy.

Mots clés: nanoscale drug-delivery system; inhibitors; combination therapy; cancer treatment; proteases

Domaines: Sciences de l'ingénieur [physics]; Chimie; Physique [physics]

Magdalena Rudzińska, Cenk Daglioglu, Lyudmila Savvateeva, Fatma Necmiye Kaci, Rodolphe Antoine, et al.. Current Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy. Drug Design, Development and Therapy, 2021, 15, pp.9-20. ⟨10.2147/DDDT.S285852⟩. ⟨hal-03128092⟩