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Magneto-mechanically actuated microstructures to efficiently prevent bacterial biofilm formation

Abstract : Bioflm colonisation of surfaces is of critical importance in various areas ranging from indwelling medical devices to industrial setups. Of particular importance is the reduced susceptibility of bacteria embedded in a bioflm to existing antimicrobial agents. In this paper, we demonstrate that remotely actuated magnetic cantilevers grafted on a substrate act efciently in preventing bacterial bioflm formation. When exposed to an alternating magnetic feld, the fexible magnetic cantilevers vertically defect from their initial position periodically, with an extremely low frequency (0.16 Hz). The cantilevers’ beating prevents the initial stage of bacterial adhesion to the substrate surface and the subsequent bioflm growth. Our experimental data on E. coli liquid cultures demonstrate up to a 70% reduction in bioflm formation. A theoretical model has been developed to predict the amplitude of the cantilevers vertical defection. Our results demonstrate proof-of-concept for a device that can magneto-mechanically prevent the frst stage in bacterial bioflm formation, acting as on-demand fouling release active surfaces.
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https://hal.archives-ouvertes.fr/hal-03115115
Contributor : Hélène Joisten <>
Submitted on : Tuesday, January 19, 2021 - 1:57:50 PM
Last modification on : Thursday, January 21, 2021 - 3:17:29 AM

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S. Leulmi Pichot, Hélène Joisten, A. Grant, B. Dieny, R. Cowburn. Magneto-mechanically actuated microstructures to efficiently prevent bacterial biofilm formation. Scientific Reports, Nature Publishing Group, 2020, Scientific Reports, 10 (15470), 12pp. ⟨10.1038/s41598-020-72406-8⟩. ⟨hal-03115115⟩

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