Practical Gram-Scale Synthesis of Either α- or β-Anomer of C-Vinyl Glycosides

Florian Rouzier (1) , Rosanne Sillé (1) , Arnaud Nourry (1) , Arnaud Tessier (2) , Muriel Pipelier (2) , Stéphane Guillarme (1)

1 IMMM - Institut des Molécules et Matériaux du Mans
2 CEISAM - Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation

The synthesis C-vinyl glycosides, useful intermediates for the synthesis of C-glycoconjugates, was carried out on gram-scale by controlled reduction of the corresponding ethynyl derivatives in good to excellent yields in different carbohydrate series.

Mots clés: C-glycosides; controlled reduction; alkynes; gram-scale

Domaines: Chimie

Florian Rouzier, Rosanne Sillé, Arnaud Nourry, Arnaud Tessier, Muriel Pipelier, et al.. Practical Gram-Scale Synthesis of Either α- or β-Anomer of C-Vinyl Glycosides. Synthesis: Journal of Synthetic Organic Chemistry, 2019, 51 (12), pp.2484-2488. ⟨10.1055/s-0037-1611800⟩. ⟨hal-03086861⟩