An Early Stage Researcher’s Primer on Systems Medicine Terminology

Massimiliano Zanin (1) , Nadim A. A. Aitya (2) , José Basilio (3) , Jan Baumbach (4) , Arriel Benis (5) , Chandan K. Behera (2) , Magda Bucholc (2) , Filippo Castiglione (6) , Ioanna Chouvarda (7) , Blandine Comte (8) , Tien-Tuan Dao (9) , Xuemei Ding (2) , Estelle Pujos-Guillot (10) , Nenad Filipovic (11) , David P. Finn (12) , David H. Glass (2) , Nissim Harel (5) , Tomas Iesmantas (13) , Ilinka Ivanoska (14) , Alok Joshi (2) , Karim Zouaoui Boudjeltia (15) , Badr Kaoui (9) , Daman Kaur (2) , Liam P. Maguire (2) , Paula L. Mcclean (2) , Niamh Mccombe (2) , João Luís De Miranda (16) , Mihnea Alexandru Moisescu (17) , Francesco Pappalardo (18) , Annikka Polster (19) , Girijesh Prasad (2) , Damjana Rozman (20) , Ioan Sacala (17) , Jose M. Sanchez-Bornot (2) , Johannes A. Schmid (3) , Trevor Sharp (21) , Jordi Solé-Casals (22) , Vojtěch Spiwok (23) , George M. Spyrou (24) , Egils Stalidzans (25) , Blaž Stres (20) , Tijana Sustersic (11) , Ioannis Symeonidis (26) , Paolo Tieri (6) , Stephen Todd , Kristel Van Steen (27) , Milena Veneva , Da-Hui Wang (28) , Haiying Wang (2) , Hui Wang (2) , Steven Watterson (2) , Kongfatt Wong-Lin (2) , Su Yang (2) , Xin Zou (29) , Harald H. H. W.Schmidt (30)

1 UPM - Universidad Politécnica de Madrid
2 University of Ulster
3 Medizinische Universität Wien = Medical University of Vienna
4 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
5 HIT - Holon Institut of Technology
6 INSEAN - CNR
7 Aristotle University of Thessaloniki
8 UNH - Unité de Nutrition Humaine
9 BMBI - Biomécanique et Bioingénierie
10 INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement
11 University of Kragujevac
12 NUI Galway - National University of Ireland [Galway]
13 KTU - Kaunas University of Technology
14 UKIM - Ss. Cyril and Methodius University in Skopje
15 ULB - Université libre de Bruxelles
16 Universidade de Lisboa
17 UPB - University Politehnica of Bucharest [Romania]
18 Unict - Università degli studi di Catania = University of Catania
19 NCMM - Centre for Molecular Medicine Norway
20 University of Ljubljana
21 University of Oxford
22 NKU - Nankai University
23 UCT Prague - University of Chemistry and Technology Prague
24 The Cyprus Institute of Neurology and Genetics
25 LU - University of Latvia
26 Hellenic Institute of Transport (H.I.T.)
27 Université de Liège
28 BNU - Beijing Normal University
29 Shanghai Jiao Tong University [Shanghai]
30 Maastricht University [Maastricht]

Background: Systems Medicine is a novel approach to medicine, i.e. an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral different fields, including medicine, biology, statistics, modelling and simulation, and data science. Such heterogeneity leads to semantic issues, which may slow down implementation and fruitful interaction between these highly diverse fields. Methods: In this review we collect and explain over one hundred terms related to Systems Medicine. These include both modelling and data science terms and basic systems medicine terms, along with some synthetic definitions, examples of applications, and lists of relevant references. Results: This glossary aims at being a first aid kit for the Systems Medicine researcher facing an unfamiliar term, where he/she can get a first understanding of them, and, more importantly, examples and references for keep digging into the topic.

Mots clés: Multi-scale modelling; Multi-scale data science; Systems medicine; Medicine; Machine learning; Graphs and Networks; Genetics

Domaines: Informatique [cs]; Sciences du Vivant [q-bio]

Massimiliano Zanin, Nadim A. A. Aitya, José Basilio, Jan Baumbach, Arriel Benis, et al.. An Early Stage Researcher’s Primer on Systems Medicine Terminology. Network and Systems Medicine, 2020, 4 (1), pp.2-50. ⟨10.1089/nsm.2020.0003⟩. ⟨hal-03064356⟩