Electrochemical tandem trifluoromethylation of allylamines/formal (3 + 2)-cycloaddition for the rapid access to CF 3 -containing imidazolines and oxazolidines

Aurélie Claraz (1) , Aurélie Djian (1) , Geraldine Masson (1)

1 ICSN - Institut de Chimie des Substances Naturelles

An electrochemical tandem radical trifluoromethylation of allylamines/formal (3+2)-cycloaddition with nitrile and carbonyl compounds has been developed under mild and environmentally benign reaction conditions. Such multicomponent reaction allowed the construction of CF 3-containing imidazolines and oxazolidines by creating three new bonds from simple and easily available starting materials.

Domaines: Chimie organique

Aurélie Claraz, Aurélie Djian, Geraldine Masson. Electrochemical tandem trifluoromethylation of allylamines/formal (3 + 2)-cycloaddition for the rapid access to CF 3 -containing imidazolines and oxazolidines. Organic Chemistry Frontiers, 2021, 8, pp.288. ⟨10.1039/D0QO01307B⟩. ⟨hal-03058541⟩