The involvement of extracellular matrix proteins in the re-epithelialization of skin wounds

Patricia Rousselle (1) , Marine Montmasson (1) , Cécile Garnier (1)

1 LBTI - Laboratoire de Biologie Tissulaire et d'ingénierie Thérapeutique UMR 5305

The ability of skin to act as a barrier is primarily determined by cells that maintain the continuity and integrity of skin and restore it after injury. Cutaneous wound healing in adult mammals is a complex multi-step process that involves overlapping stages of blood clot formation, inflammation, re-epithelialization, granulation tissue formation, neovascularization, and remodeling. Under favorable conditions, epidermal regeneration begins within hours after injury and takes several days until the epithelial surface is intact due to reorganization of the basement membrane. Regeneration relies on numerous signaling cues and on multiple cellular processes that take place both within the epidermis and in other participating tissues. A variety of modulators are involved, including growth factors, cytokines, matrix metalloproteinases, cellular receptors, and extracellular matrix components. Here we focus on the involvement of the extracellular matrix proteins that impact epidermal regeneration during wound healing.

Mots clés: basement membrane; re-epithelialization; dermal-epidermal junction; extracellular matrix; laminin; epidermal regeneration; keratinocyte; wound healing

Domaines: Sciences du Vivant [q-bio]; Biochimie [q-bio.BM]; Biologie cellulaire; Réseaux moléculaires [q-bio.MN]

Patricia Rousselle, Marine Montmasson, Cécile Garnier. The involvement of extracellular matrix proteins in the re-epithelialization of skin wounds. Matrix Biology, 2019, 75-76, pp.12-26. ⟨10.1016/j.matbio.2018.01.002⟩. ⟨hal-03034642⟩