HPV cervical infections and serological status in vaccinated and unvaccinated women

Carmen Lia Murall (1) , Bastien Reyné (1) , Christian Selinger (1) , Claire Bernat (1) , Vanina Boué (1) , Sophie Grasset (1) , Soraya Groc (1) , Massilva Rahmoun (1) , Noemi Bender (2) , Marine Bonneau (3) , Vincent Foulongne (4, 5) , Christelle Graf (3) , Eric Picot (3) , Marie-Christine Picot (3) , Vincent Tribout (3) , Tim Waterboer (2) , Ignacio Bravo (1) , Jacques Reynes (6, 7) , Michel Segondy (4, 5) , Nathalie Boulle (4, 5) , Samuel Alizon (8, 9)

1 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
2 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
3 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
4 Service de Biopathologie [CHRU Montpellier]
5 Pathogénèse et contrôle des infections chroniques (PCCI)
6 Département Maladies Infectieuses et Tropicales, Hôpital Universitaire, Montpellier, France
7 TransVIHMI - Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes
8 MIVEGEC-ETE - Evolution Théorique et Expérimentale
9 CIRB - Centre interdisciplinaire de recherche en biologie

Understanding genital infections by Human papillomaviruses (HPVs) remains a major public health issue, especially in countries where vaccine uptake is low. We investigate HPV prevalence and antibody status in 150 women (ages 18 to 25) in Montpellier, France. At inclusion and one month later, cervical swabs, blood samples and questionnaires (for demographics and behavioural variables) were collected. Oncogenic, non-vaccine genotypes HPV51, HPV66, HPV53, and HPV52 were the most frequently detected viral genotypes overall. Vaccination status, which was well-balanced in the cohort, showed the strongest (protective) eect against HPV infections, with an associated odds ratio for alphapapillo-mavirus detection of 0.45 (95% condence interval: [0.22;0.58]). We also identied signicant eects of age, number of partners, body mass index, and contraception status on HPV detection and on coinfec-tions. Type-specic IgG serological status was also largely explained by the vaccination status. IgM seropositivity was best explained by HPV detection at inclusion only. Finally, we identify a strong signicant eect of vaccination on genotype prevalence, with a striking under-representation of HPV51 in vaccinated women. Variations in HPV prevalence correlate with key demographic and behavioural variables. The cross-protective eect of the vaccine against HPV51 merits further investigation.

Mots clés: HPV; vaccination; serology; cross-protection; acute infections; genital infections

Domaines: Modélisation et simulation; Biodiversité et Ecologie; Santé publique et épidémiologie; Bio-Informatique, Biologie Systémique [q-bio.QM]; Evolution [q-bio.PE]; Systématique, phylogénie et taxonomie; Ecosystèmes; Interactions entre organismes; Santé; Génétique des populations [q-bio.PE]; Virologie

Carmen Lia Murall, Bastien Reyné, Christian Selinger, Claire Bernat, Vanina Boué, et al.. HPV cervical infections and serological status in vaccinated and unvaccinated women. Vaccine, 2020, 38 (51), pp.8167-8174. ⟨10.1016/j.vaccine.2020.10.078⟩. ⟨hal-03001077v2⟩