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Peer presence and familiarity as key factors to reduce cocaine intake: evidence from translational researc

Résumé : Social environment influences drug consumption, its persistence and evolution. Little is known regarding the influence of the presence of a peer during drug consumption and especially how the relationship between peers (familiarity and dominance) can influence drug consumption. We used here a translational and transdisciplinary approach to explore the influence of peer presence and peer familiarity in rats and humans that self-administer stimulants. In rats, cocaine intake was compared when rats were alone with intake when peers with different characteristics (familiar or not, cocaine naive or not, dominant or subordinate) were present. In humans, 77 cocaine and/or methylphenidate users were asked to detail their most recent drug use episodes and their relationship with peers present at consumption. The results show that in both humans and rats, the risk of cocaine/stimulant consumption was significantly reduced by 37% and 32%, respectively, when a peer was present. Moreover, the lowest risk of consumption was consistently observed when the peer was unfamiliar (vs familiar) with a further 38% and 17% risk reduction, respectively. In rats, a decreased risk of consumption was greater when the peer was cocaine naive (vs non-cocaine naive).
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https://hal.archives-ouvertes.fr/hal-02990844
Contributor : Christelle Baunez Connect in order to contact the contributor
Submitted on : Tuesday, November 10, 2020 - 12:32:31 PM
Last modification on : Wednesday, November 3, 2021 - 9:56:31 AM

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Elodie Giorla, S Nordmann, Y Pelloux, P Roux, S Rosellini, et al.. Peer presence and familiarity as key factors to reduce cocaine intake: evidence from translational researc. 2020. ⟨hal-02990844⟩

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