Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis

Marina Peralta (1) , Laia Ortiz Lopez (1) , Katerina Jerabkova (1) , Tommaso Lucchesi (2) , Benjamin Vitre (3) , Dong Han (2) , Laurent Guillemot (2) , Chaitanya Dingare (4) , Izabela Sumara (1) , Nadia Mercader (5, 6) , Virginie Lecaudey (4) , Benedicte Delaval (3) , Sigolène Meilhac (2) , Julien Vermot (1, 7)

1 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
2 Imagine - Institut Pasteur U1163 - Morphogenèse du cœur - Heart morphogenesis
3 CRBM - Centre de recherche en Biologie cellulaire de Montpellier
4 Goethe University Frankfurt
5 UNIBE - Universität Bern / University of Bern
6 CNIC - Centro Nacional de Investigaciones Cardiovasculares Carlos III [Madrid, Spain]
7 Imperial College London

Highlights d IFT proteins restrict proepicardial and myocardial development d IFT proteins act independently of primary cilia in this process d IFT proteins modulate BMP signaling by tuning Yap1-Tead activity d IFT88 and IFT20 interact with YAP1 in the cytoplasm to set Yap1-Tead activity

Domaines: Sciences du Vivant [q-bio]; Embryologie et organogenèse

Marina Peralta, Laia Ortiz Lopez, Katerina Jerabkova, Tommaso Lucchesi, Benjamin Vitre, et al.. Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis. Cell Reports, 2020, 32 (3), pp.107932. ⟨10.1016/j.celrep.2020.107932⟩. ⟨hal-02989229⟩