XAB2 prevents abortive recombinational repair of replication-associated DNA double-strand breaks and its loss is synthetic lethal with RAD52 inhibition

Abhishek B Sharma (1) , Hélène Erasimus (1) , Lia Pinto (1) , Marie-Christine Caron (2) , Katrin Neumann (1) , Petr V Nazarov (1) , Barbara Klink (1) , Sabrina Fritah (1) , Christel C Herold-Mende (3) , Simone P Niclou (1) , Patrick Calsou (4, 5) , Jean-Yves Masson (2) , Sébastien Britton (4, 6) , Eric van Dyck (1)

1 LIH - Luxembourg Institute of Health
2 Axe Oncologie [CRCHU de Québec]
3 University clinic Heidelberg
4 IPBS - Institut de pharmacologie et de biologie structurale
5 INSERM - Institut National de la Santé et de la Recherche Médicale
6 CNRS - Centre National de la Recherche Scientifique

Domaines: Biochimie, Biologie Moléculaire; Cancer; Génétique

Abhishek B Sharma, Hélène Erasimus, Lia Pinto, Marie-Christine Caron, Katrin Neumann, et al.. XAB2 prevents abortive recombinational repair of replication-associated DNA double-strand breaks and its loss is synthetic lethal with RAD52 inhibition. 2020. ⟨hal-02989098⟩