Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system
Résumé
The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq l -1. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lymphohematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. © Springer-Verlag 2010.
Mots clés
Biodistributions
Blood cells
Bone marrow
Bone marrow cells
Concentration of
Drinking water
Hematopoietic systems
Mononuclear cells
Mouse models
Phenotypic analysis
Animals
Blood
Bone
Cell culture
Cell proliferation
Potable water
Cesium
Animalia
cesium
cytokine
age
animal
animal model
article
Bagg albino mouse
blood
blood cell count
cytology
drinking
eating
female
fetus
hematopoietic system
male
mouse
phenotype
radiation exposure
reproduction
time
Age Factors
Blood Cell Count
Cesium Radioisotopes
Cytokines
Drinking
Eating
Female
Fetus
Hematopoietic System
Male
Mice
Inbred BALB C
Models
Animal
Phenotype
Reproduction
Time Factors