Distribution of 137cs in rat tissues after various schedules of chronic ingestion
Résumé
The aim of this work was to compare the distribution of 137Cs in organisms after chronic ingestion following different schedules. Rats were contaminated through drinking water containing 6,500 Bq L-1 of 137Cs, starting either at birth, at weaning, or upon reaching adult age (13 wk). Animals were then sacrificed after different durations of ingestion. 137Cs content of organs and excreta were determined by γ counting. A slight decrease in Cs elimination through urine was observed according to the age of animals. All organs tested showed similar 137Cs content, with the exception of striated muscles and the thyroid at certain ages, which showed the highest accumulation of Cs. The lowest 137Cs concentration was found in the blood, which acts as a transfer compartment after absorption in the intestine. Substructures of the central nervous system showed a homogeneous level of 137Cs accumulation, except for the olfactive bulbs. In these structures, an increased concentration of 137Cs was observed, suggesting a possible direct route of intake through the nasal epithelium. Overall, these results are in agreement with current models for the biokinetics of 137Cs. However, these results also suggest that the thyroid should be taken into account in future models of 137Cs biokinetics. Copyright © 2010 Health Physics Society.
Mots clés
Animalia
Mus
Rattus
cesium
aging
animal
antibody specificity
article
drinking
intestine
metabolism
newborn
nose mucosa
olfactory bulb
oral drug administration
radioactive contamination
rat
relative biologic effectiveness
Sprague Dawley rat
time
tissue distribution
weaning
Administration
Oral
Aging
Animals
Newborn
Cesium Radioisotopes
Drinking
Food Contamination
Radioactive
Intestines
Nasal Mucosa
Olfactory Bulb
Organ Specificity
Rats
Sprague-Dawley
Relative Biological Effectiveness
Time Factors
Tissue Distribution
Weaning