An Individual-Centered Framework For Unravelling Genotype-Phenotype Interactions

Michel Baguette (1) , Delphine Legrand (1) , Virginie Marie Stevens (1)

1 SEEM - Station d’Ecologie Expérimentale du CNRS à Moulis

A new framework in which the multiple levels of molecular variations contribute to phenotypic variations in a complex, nonlinear and interactive way, challenges the hierarchical nature of the relationships between the genotypic and phenotypic spaces. This individual-centered framework provides new insights on the evolutionary mechanisms involved in the production of phenotypes. We propose to move this research agenda forward by combining selection experiments and functional genetics.

Mots clés: genome; epigenome; proteome; phenome; syndrome; molecular pedigree of evolutionary changes

Domaines: Sciences du Vivant [q-bio]

Michel Baguette, Delphine Legrand, Virginie Marie Stevens. An Individual-Centered Framework For Unravelling Genotype-Phenotype Interactions. Trends in Ecology & Evolution, 2015, 30 (12), pp.709-711. ⟨10.1016/j.tree.2015.10.003⟩. ⟨hal-02960212⟩