A bicyclic unit reversal to stabilize the 12/14-helix in mixed homochiral oligoureas

Pierre Milbeo (1) , Matthieu Simon (1) , Claude Didierjean (2, 3) , Emmanuel Wenger (2, 3) , Emmanuel Aubert (2, 3) , Jean Martinez (1) , Muriel Amblard (1) , Monique Calmès (1) , Baptiste Legrand (1)

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
2 FST - Faculté des Sciences et Technologies [Université de Lorraine]
3 CRM2 - Cristallographie, Résonance Magnétique et Modélisations

The insertion of cyclic building blocks in oligoureas to stabilize or modulate the properties of the 12/14-helix was often fruitless. We herein propose a fully compatible highly constrained building block that could be incorporated into oligoureas to develop highly stable and functionnal oligoureas helices.

Domaines: Autre [cond-mat.other]; Chimie organique

Pierre Milbeo, Matthieu Simon, Claude Didierjean, Emmanuel Wenger, Emmanuel Aubert, et al.. A bicyclic unit reversal to stabilize the 12/14-helix in mixed homochiral oligoureas. Chemical Communications, 2020, 56 (57), pp.7921-7924. ⟨10.1039/d0cc02902e⟩. ⟨hal-03080580⟩