Dysfunctional T Cell Mitochondria Lead to Premature Aging

Guy Lenaers (1, 2) , Dominique Bonneau (1, 2, 3) , Yves Delneste (4, 2, 3) , Nicolas Papon (2, 5)

1 MITOVASC - MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale
2 ICAT - SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques
3 CHU Angers - Centre Hospitalier Universitaire d'Angers
4 CRCINA-ÉQUIPE 7 - Innate Immunity and Immunotherapy
5 GEIHP - Groupe d'Étude des Interactions Hôte-Pathogène

Desdín-Micó et al. have shown that Tfam specific knockout in mouse T cells disrupts mitochondrial genome integrity and induces a burst of inflammatory cytokines and tumor necrosis factor (TNF)-α production, resulting in increased senescence, neuromuscular and vascular dysfunction, and molecular features that recapitulate premature aging. Interestingly, treatment with nicotinamide riboside (NR) alleviates this phenotype by reducing senescence and systemic inflammation.

Mots clés: T cells; cytokine; mitochondria; premature aging; senescence

Domaines: Sciences du Vivant [q-bio]

Guy Lenaers, Dominique Bonneau, Yves Delneste, Nicolas Papon. Dysfunctional T Cell Mitochondria Lead to Premature Aging. Trends in Molecular Medicine, 2020, 26 (9), pp.799-800. ⟨10.1016/j.molmed.2020.07.001⟩. ⟨hal-02942791⟩