Hormones Secretion and Rho GTPases in Neuroendocrine Tumors

Laura Streit (1) , Laurent Brunaud (2, 3) , Nicolas Vitale (1) , Stéphane Ory (1) , Stephane Gasman (4)

1 INCI - Institut des Neurosciences Cellulaires et Intégratives
2 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
3 UL - Université de Lorraine
4 Équipe "Rythme, vie et mort de la rétine"

Neuroendocrine tumors (NETs) belong to a heterogeneous group of neoplasms arising from hormone secreting cells. These tumors are often associated with a dysfunction of their secretory activity. Neuroendocrine secretion occurs through calcium-regulated exocytosis, a process that is tightly controlled by Rho GTPases family members. In this review, we compiled the numerous mutations and modification of expression levels of Rho GTPases or their regulators (Rho guanine nucleotide-exchange factors and Rho GTPase-activating proteins) that have been identified in NETs. We discussed how they might regulate neuroendocrine secretion.

Mots clés: neuroendocrine tumors; Rho GTPases; hormone secretion; vesicular trafficking; mutations; expression changes

Domaines: Cancer; Neurobiologie; Endocrinologie et métabolisme

Laura Streit, Laurent Brunaud, Nicolas Vitale, Stéphane Ory, Stephane Gasman. Hormones Secretion and Rho GTPases in Neuroendocrine Tumors. Cancers, 2020, 12 (7), pp.1859. ⟨10.3390/cancers12071859⟩. ⟨hal-02922312⟩