A terbium(III) luminescent ATCUN-based peptide sensor for selective and reversible detection of copper(II) in biological media

Enrico Falcone (1) , Paulina Gonzalez (1) , Lucie Lorusso (1) , Olivier Sénèque (2) , Peter Faller (1) , Laurent Raibaut (1)

1 Institut de Chimie de Strasbourg
2 PMB - Physiochimie des Métaux

The measurement of exchangeable Cu2+ levels in biological samples is gaining interest in the context of copper-related pathologies. Here, we report a Tb3+ luminescent turn-off sensor for Cu2+ based on the specific and suitable-affinity Xxx-Zzz-His (ATCUN) peptide motif, enabling Cu2+ detection in the presence of a biological fluorescent background.

Domaines: Chimie de coordination

Enrico Falcone, Paulina Gonzalez, Lucie Lorusso, Olivier Sénèque, Peter Faller, et al.. A terbium(III) luminescent ATCUN-based peptide sensor for selective and reversible detection of copper(II) in biological media. Chemical Communications, 2020, 56 (35), pp.4797-4800. ⟨10.1039/D0CC01007C⟩. ⟨hal-02917280⟩