Human Serum Albumin-Alginate Esters Microparticles Prepared by Transacylation: Effect of Ester Group

Imane Hadef (1) , Mehdi Omri (1) , Christophe Bliard (1, 2) , Barbara Rogé (1) , Florence Edwards-Lévy (1)

1 ICMR - Institut de Chimie Moléculaire de Reims - UMR 7312
2 CNRS - Centre National de la Recherche Scientifique

Microencapsulation using the transacylation reaction in a W/O emulsion is based on the creation of amide bonds between free amine functions of a protein and polysaccharide ester groups in the aqueous phase after alkalization. Several proteins have been implicated in this process, whereas commercial propylene glycol alginate (PGA) has been the only modified polysaccharide used up to now (1,2). The intrinsic properties of PGA such as viscosity, molecular mass, ester type and substitution degree limit its use in microparticle preparation hence the need to study other potential polysaccharide esters.

Domaines: Chimie organique; Polymères; Chimie thérapeutique; Pharmacie galénique

Imane Hadef, Mehdi Omri, Christophe Bliard, Barbara Rogé, Florence Edwards-Lévy. Human Serum Albumin-Alginate Esters Microparticles Prepared by Transacylation: Effect of Ester Group. 1st European Conference on Pharmaceutics, Apr 2015, Reims, France. ⟨hal-02894581⟩