Chemo-enzymatic synthesis of glycolipids, their polymerization and self-assembly

Dounia Arcens (1, 2) , Gaëlle Le Fer (3) , Etienne Grau (2) , Stéphane Grelier (2) , Henri Cramail (2) , Frédéric Peruch (1)

1 Team 1 LCPO : Polymerization Catalyses & Engineering
2 Team 2 LCPO : Biopolymers & Bio-sourced Polymers
3 Team 3 LCPO : Polymer Self-Assembly & Life Sciences

This paper describes the synthesis of bio-based methacrylated 12-hydroxystearate glucose (MASG), and its (co)polymerization with methyl methacrylate (MMA) by either free-or RAFT radical polymerizations. The obtained amphiphilic p(MMA-MASG) copolymers self-assembled in water into various morphologies depending on the MASG unit content and glycopolymer crystallinity. Finally, as a proof of concept, a hydrophobic dye, Nile Red, was entrapped by co-nanoprecipitation into p(MMA-MASG) nanoparticles, showing their loading capacity and thus demonstrating the potential of such amphiphilic glycolipid-based copolymers in hydrophobic compound encapsulation applications.

Domaines: Polymères

Dounia Arcens, Gaëlle Le Fer, Etienne Grau, Stéphane Grelier, Henri Cramail, et al.. Chemo-enzymatic synthesis of glycolipids, their polymerization and self-assembly. Polymer Chemistry, 2020, 11 (24), pp.3994-4004. ⟨10.1039/D0PY00526F⟩. ⟨hal-02882238⟩