Luminescent pro-nitroxide lanthanide complexes for the detection of reactive oxygen species

Richard Barré (1) , Damien Mouchel Dit Leguerrier (1) , Lionel Fédèle (2) , Daniel Imbert (2, 3) , Jennifer K. Molloy (1) , Fabrice Thomas (1)

1 DCM - Département de Chimie Moléculaire
2 SYMMES - SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé
3 BioCE - Catalyse Bioinorganique et Environnement

The DOTA-based ligand H3L (5) appended with a pro-nitroxide moiety has been synthesized. The europium and ytterbium complexes 5Ln show metal-centred luminescence. They react with ROS in aqueous media to give a transient iminonitroxide and a stable nitronylnitroxide radical authenticated by EPR, with change in luminescence.

Domaines: Chimie de coordination

Richard Barré, Damien Mouchel Dit Leguerrier, Lionel Fédèle, Daniel Imbert, Jennifer K. Molloy, et al.. Luminescent pro-nitroxide lanthanide complexes for the detection of reactive oxygen species. Chemical Communications, 2020, 56 (3), pp.435-438. ⟨10.1039/c9cc06524e⟩. ⟨hal-02874020⟩