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The sheep genome illuminates biology of the rumen and lipid metabolism

Yu Jiang 1, 2, 3 Min Xie 4 Wenbin Chen 4 Richard Talbot 5 Jillian F. Maddox 6 Thomas Faraut 7 Chunhua Wu 6 Donna M. Muzny 8 Yuxiang Li 4 Wenguang Zhang 9, 10, 3 Jo-Ann Stanton 11 Rudiger Brauning 12 Wesley C. Barris 1 Thibaut Hourlier 13, 14 Bronwen L. Aken 13, 14 Stephen M. J. Searle 13 David L. Adelson 1 Chao Bian 4 Graham R. Cam 1 Yulin Chen 2 Shifeng Cheng 4 Udaya Desilva 1 Karen Dixen 15 Yang Dong 16 Guangyi Fan 4 Ian R. Franklin 1 Shaoyin Fu 9 Pablo Fuentes-Utrilla 5 Rui Guan 4 Margaret A. Highland 17, 18 Michael E. Holder 8 Guodong Huang 4 Aaron B. Ingham 1 Shalini N. Jhangiani 8 Divya Kalra 8 Christie L. Kovar 8 Sandra L. Lee 8 Weiqing Liu 4 Xin Liu 4 Changxin Lu 4 Tian Lv 4 Tittu Mathew 8 Sean Mcwilliam 1 Moira Menzies 1 Shengkai Pan 4 David Robelin 19 Bertrand Servin 19 David Townley 1 Wenliang Wang 4 Bin Wei 4, 20 Stephen N. White 17, 18 Xinhua Yang 4 Chen Ye 4 Yaojing Yue 21 Peng Zeng 4 Qing Zhou 4 Jacob B. Hansen 15 Karsten Kristiansen 15 Richard A. Gibbs 8 Paul Flicek 14 Christopher C. Warkup 22 Huw E. Jones 22 V. Hutton Oddy 23 Frank W. Nicholas 24 John C. Mcewan 12 James W. Kijas 1 Jun Wang 4, 15, 25, 26 Kim C. Worley 8, * Alan L. Archibald 27, * Noelle Cockett 6, * Xun Xu 4, * Wen Wang 3, * Brian P. Dalrymple 1, *
Abstract : Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.
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Yu Jiang, Min Xie, Wenbin Chen, Richard Talbot, Jillian F. Maddox, et al.. The sheep genome illuminates biology of the rumen and lipid metabolism. Science, American Association for the Advancement of Science, 2014, 344 (6188), pp.1168-1173. ⟨10.1126/science.1252806⟩. ⟨hal-02635391⟩

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