TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei
Sanu Shameer
(1)
,
Flora J. Logan-Klumpler
(2)
,
Florence Vinson
(3)
,
Ludovic Cottret
(4)
,
Benjamin Merlet
(1)
,
Fiona Achcar
(5)
,
Michael Boshart
(6)
,
Matthew Berriman
(2)
,
Rainer Breitling
(7)
,
Frédéric Bringaud
(8)
,
Peter Bütikofer
(9)
,
Amy M. Cattanach
(5)
,
Bridget Bannerman-Chukualim
(2)
,
Darren J. Creek
(10)
,
Kathryn Crouch
(5)
,
Harry P. de Koning
(5)
,
Hubert Denise
(11)
,
Charles Ebikeme
(12)
,
Alan H. Fairlamb
(13)
,
Michael A. J. Ferguson
(13)
,
Michael L. Ginger
(14)
,
Christiane Hertz-Fowler
(15)
,
Eduard J. Kerkhoven
(16)
,
Pascal Maeser
(17)
,
Paul A. M. Michels
(18)
,
Archana Nayak
(5)
,
David W. Nes
(19)
,
Derek P. Nolan
(20)
,
Christian Olsen
(21)
,
Fatima Silva-Franco
(15)
,
Terry K. Smith
(22)
,
Martin C. Taylor
(23)
,
Aloysius G. M. Tielens
(24, 25)
,
Michael D. Urbaniak
(14)
,
Jaap J. van Hellemond
(25)
,
Isabel M. Vincent
(5)
,
Shane R. Wilkinson
(26)
,
Susan Wyllie
(13)
,
Fred R. Opperdoes
(27)
,
Michael P. Barrett
(5)
,
Fabien Jourdan
(3)
1
ToxAlim -
ToxAlim
2 The Wellcome Trust Sanger Institute [Cambridge]
3 ToxAlim-MeX - Métabolisme et Xénobiotiques
4 LIPM - Laboratoire des interactions plantes micro-organismes
5 University of Glasgow
6 LMU - Ludwig-Maximilians University [Munich]
7 University of Manchester [Manchester]
8 CNRS - Centre National de la Recherche Scientifique
9 UNIBE - Universität Bern / University of Bern
10 Monash University
11 European Molecular Biology Laboratory European Bioinformatics Institute
12 UNESCO - United Nations Educational, Scientific and Cultural Organization
13 University of Dundee
14 Lancaster University
15 University of Liverpool
16 Chalmers University of Technology [Gothenburg, Sweden]
17 Swiss Tropical and Public Health Institute [Basel]
18 Edin. - University of Edinburgh
19 TexasTech University
20 Trinity College Dublin
21 Biomatters Inc
22 University of St Andrews [Scotland]
23 LSHTM - London School of Hygiene and Tropical Medicine
24 Universiteit Utrecht / Utrecht University [Utrecht]
25 Erasmus University Rotterdam
26 QMUL - Queen Mary University of London
27 UCL - Université Catholique de Louvain = Catholic University of Louvain
2 The Wellcome Trust Sanger Institute [Cambridge]
3 ToxAlim-MeX - Métabolisme et Xénobiotiques
4 LIPM - Laboratoire des interactions plantes micro-organismes
5 University of Glasgow
6 LMU - Ludwig-Maximilians University [Munich]
7 University of Manchester [Manchester]
8 CNRS - Centre National de la Recherche Scientifique
9 UNIBE - Universität Bern / University of Bern
10 Monash University
11 European Molecular Biology Laboratory European Bioinformatics Institute
12 UNESCO - United Nations Educational, Scientific and Cultural Organization
13 University of Dundee
14 Lancaster University
15 University of Liverpool
16 Chalmers University of Technology [Gothenburg, Sweden]
17 Swiss Tropical and Public Health Institute [Basel]
18 Edin. - University of Edinburgh
19 TexasTech University
20 Trinity College Dublin
21 Biomatters Inc
22 University of St Andrews [Scotland]
23 LSHTM - London School of Hygiene and Tropical Medicine
24 Universiteit Utrecht / Utrecht University [Utrecht]
25 Erasmus University Rotterdam
26 QMUL - Queen Mary University of London
27 UCL - Université Catholique de Louvain = Catholic University of Louvain
Florence Vinson
- Fonction : Auteur
- PersonId : 1206250
- IdHAL : florence-vinson
- ORCID : 0000-0001-8143-8183
Ludovic Cottret
- Fonction : Auteur
- PersonId : 801411
- IdHAL : lcottret
- ORCID : 0000-0001-7418-7750
- IdRef : 172201861
Michael Boshart
- Fonction : Auteur
- PersonId : 761859
- ORCID : 0000-0002-5070-2663
Frédéric Bringaud
- Fonction : Auteur
- PersonId : 758546
- ORCID : 0000-0003-4552-6877
- IdRef : 060946725
Fabien Jourdan
- Fonction : Auteur
- PersonId : 736810
- IdHAL : fabien-jourdan
- ORCID : 0000-0001-9401-2894
- IdRef : 069183996
Résumé
The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions. Our understanding of individual metabolic networks is increasing as we learn more about the enzymes that are active in particular cells under particular conditions and as technologies advance to allow detailed measurements of the cellular metabolome. Metabolic network databases are of increasing importance in allowing us to contextualise data sets emerging from transcriptomic, proteomic and metabolomic experiments. Here we present a dynamic database, TrypanoCyc ( ext-link-type="uri" xlink:href="http://www.metexplore.fr/trypanocyc/" xlink:type="simple">http://www.metexplore.fr/trypanocyc/), which describes the generic and condition-specific metabolic network of Trypanosoma brucei, a parasitic protozoan responsible for human and animal African trypanosomiasis. In addition to enabling navigation through the BioCyc-based TrypanoCyc interface, we have also implemented a network-based representation of the information through MetExplore, yielding a novel environment in which to visualise the metabolism of this important parasite.
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...