Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25 years of research in chemistry and biology

Jean-Marie Galano (1) , Yiu Yiu Lee (2) , Camille Oger (1) , Claire Vigor (1) , Joseph Vercauteren (1) , Thierry Durand (1) , Martin Giera (3) , Jetty Chung-Yung Lee (4, 2)

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
2 HKU - The University of Hong Kong
3 LUMC - Leiden University Medical Center
4 School of Biological Sciences, Faculty of Sciences

Since the beginning of the 1990's diverse types of metabolites originating from polyunsaturated fatty acids, formed under autooxidative conditions were discovered. Known as prostaglandin isomers (or isoprostanoids) originating from arachidonic acid, neuroprostanes from docosahexaenoic acid, and phytoprostanes from α-li-nolenic acid proved to be prevalent in biology. The syntheses of these compounds by organic chemists and the development of sophisticated mass spectrometry methods has boosted our understanding of the isoprostanoid biology. In recent years, it has become accepted that these molecules not only serve as markers of oxidative damage but also exhibit a wide range of bioactivities. In addition, isoprostanoids have emerged as indicators of oxidative stress in humans and their environment. This review explores in detail the isoprostanoid chemistry and biology that has been achieved in the past three decades.

Domaines: Chimie; Chimie organique; Chimie analytique; Biochimie [q-bio.BM]; Sciences du Vivant [q-bio]; Médecine humaine et pathologie

Jean-Marie Galano, Yiu Yiu Lee, Camille Oger, Claire Vigor, Joseph Vercauteren, et al.. Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25 years of research in chemistry and biology. Progress in Lipid Research, 2017, 68, pp.83-108. ⟨10.1016/j.plipres.2017.09.004⟩. ⟨hal-02594327⟩